The purpose of this study is to see how well Photon Counting CT (PCCT) and ultrasound test results can find fat and scarring in the liver. They will be compared to MRI test results as the reference standard. Participants will get a regular CT scan on the PCCT scanner, plus a few extra pictures just for the study. They will also get an MRI, either on the same day or a different day, whichever is preferred. Participants will get an ultrasound on the same day as the MRI. If they have not had a hematocrit blood test in the past 24 hours, they will also receive one on the day of the CT scan.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
45
Photon-counting computed tomography (PCCT) is a next-generation imaging technology using advanced detectors that directly count individual X-ray photons and measure their energy, rather than integrating total energy like traditional CT.
Ultrasound is a safe, radiation-free imaging technique using high-frequency sound waves to visualize soft tissues, organs, and blood flow in real-time.
MRI is a noninvasive, radiation-free medical imaging technique that uses powerful magnets and radio waves to generate detailed, high-resolution 3D images of soft tissues, organs, and bones.
Duke University Medical Center
Durham, North Carolina, United States
RECRUITINGSensitivity of CT-FF (computed tomography fat fraction)
The percentage of patients with hepatic steatosis by MRI-PDFF who have positive CT-PDFF.
Time frame: 1 day to 14 days
Specificity of CT-FF (computed tomography fat fraction)
The percentage of patients without hepatic steatosis by MRI-PDFF who have negative CT-PDFF.
Time frame: 1 day to 14 days
Sensitivity of Ultrasound-Derived Fat Fraction (UDFF)
The percentage of patients with hepatic steatosis by MRI-PDFF who have positive UDFF.
Time frame: 1 day to 14 days
Specificity of Ultrasound-Derived Fat Fraction (UDFF)
The percentage of patients without hepatic steatosis by MRI-PDFF who have negative UDFF.
Time frame: 1 day to 14 days
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