Retrospective Study on Ventilator Weaning Outcomes in Patients With Acute Brain Injury

Southeast University, China

Overview

Invasive mechanical ventilation (IMV) is a life-saving supportive therapy for patients with acute brain injury, which accounted for nearly one-fifth of all mechanically ventilated patients in the intensive care unit (ICU). However, prolonged exposure to IMV is consistently associated with an increased risk of ventilator-related complications and adverse outcomes. Accordingly, alongside the initiation of IMV, timely and safe liberation from ventilator should be considered. Nevertheless, data detailing the weaning process and its associated outcomes in mechanically ventilated patients with ABI remain scarce. To address this gap, the investigators conducted an observational study aimed at characterizing the ventilator weaning process and outcomes in patients with ABI receiving IMV, using the modified WIND classification.

Study Type

OBSERVATIONAL

Conditions

Acute Brain Injuries Mechanical Ventilation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with ABI * ≥ 18 years old * underwent IMV for at least 24 hours Exclusion Criteria: * already tracheostomized * concurrent of cervical spinal cord injury * pregnant or lactation * withdraw of life-sustaining treatment within the first 24 hours of ICU admission

Locations (1)

Department of Critical Care Medicine, Zhongda Hospital

Nanjing, Jiangsu, China

Outcomes

Primary Outcomes

weaning outcome

The primary endpoint was the weaning outcome according to the modified WIND classification

Time frame: day 90

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.