The main aim of this study is to evaluate the impact and identify potential indications for sequential double embryo transfer (SEQ-ET) in couples undergoing assisted reproductive technology (ART). The study will compare live birth rates (LBR) between patients receiving SEQ-ET and those receiving standard double embryo transfer (DET), while assessing safety outcomes and potential indications, including endometrial immune under-activation. Each SEQ-ET case will be matched with a DET control based on age, transfer attempt rank, and ART technique. We hypothesize that SEQ-ET may enhance implantation in couples with previous ART failures without increasing the risk of complications, potentially through localized maternal-endometrial immune communication initiated by the initially transferred cleavage-stage embryos.
Study Type
OBSERVATIONAL
Enrollment
778
Hôpital Pierre Rouquès - Les Bluets.
Paris, France
Live birth rate
LBR defined as delivery of a viable infant beyond 24 weeks of gestation, assessed after the first fresh or frozen blastocyst transfer.
Time frame: From first embryo transfer to delivery (up to approximately 9 months).
Clinical Pregnancy Rate
Clinical pregnancy confirmed by ultrasound visualization of a gestational sac.
Time frame: 6-8 weeks after embryo transfer.
Miscarriage Rate per Clinical Pregnancy
Pregnancy loss before 24 weeks of gestation among clinical pregnancies.
Time frame: Up to 24 weeks of gestation.
Implantation Rate
Number of gestational sacs per number of embryos transferred.
Time frame: 6-8 weeks after embryo transfer.
Multiple pregnancies
Percentage of multiple pregnancies regardless of whether one or two day-2/3 are transferred before the day-5 embryo are transferred.
Time frame: Up to 9 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.