* PRF performed on the sphenopalatine ganglion level under ultrasound guidance. * Standard voltage PRF parameters: 45 V, 5 Hz frequency, 5 ms pulse width, 360 seconds duration, electrode temperature ≤42°C. * Supravoltage PRF parameters: Higher voltage than standard (e.g., 60-70 V), with same frequency, pulse width, and duration, maintaining temperature ≤42°C to avoid nerve damage.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
100
• Standard voltage PRF parameters: 45 V, 5 Hz frequency, 5 ms pulse width, 360 seconds duration, electrode temperature ≤42°C.
• Supravoltage PRF parameters: Higher voltage than standard (e.g., 60-70 V), with same frequency, pulse width, and duration, maintaining temperature ≤42°C to avoid nerve damage.
Minia university raouf
Minya, Egypt
RECRUITINGMinia university
Minya, Egypt
RECRUITINGProportion of participants achieving ≥50% reduction in monthly migraine days from baseline Baseline MMD is determined using a 4-week prospective headache diary prior.
A day is counted as a migraine day if: Headache lasts ≥4 hours OR Shorter but treated with migraine-specific medication (e.g., triptan)
Time frame: 3 MONTHS POST INTERVENTIONAL
proportion of population with ≥50% reduction in VAS score from preinterventional values
VAS 1-3 MILD PAIN 4-5= MODERATE \>6 SEVERE PAIN
Time frame: 1 week, 1 month, 3,6 months POST INTERVENTIONAL
procedure related complications
Local: bleeding, hematoma, infection Neurological: facial numbness, dysesthesia, neuralgia Autonomic: lacrimation, nasal congestion Auditory: tinnitus Serious adverse events: intracranial injury, vascular injury
Time frame: UP TO 6 months
Proportion of participants achieving ≥50% reduction in monthly migraine days from baseline Baseline MMD is determined using a 4-week prospective headache diary
A day is counted as a migraine day if: Headache lasts ≥4 hours OR Shorter but treated with migraine-specific medication (e.g., triptan)
Time frame: 1, 6 MONTHS POST INTERVENTIONAL
NUMBER OF DAYS OF ACUTE MEDICATIONS USE REPORTED MONTHLY
A medication-use day was defined as any day on which at least one dose of acute migraine medication was taken, regardless of the number of doses."
Time frame: 1,2,3,4,5,6 MONTHS
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