The objective of this study is to assess the effect of repeated doses of ABBV-722 on the single dose pharmacokinetics (PK) of ethinyl estradiol and levonorgestrel.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
15
Oral
Acpru /Id# 281745
Grayslake, Illinois, United States
Maximum Observed Plasma Concentration (Cmax) of Ethinyl Estradiol and Levonorgestrel
Cmax of Ethinyl Estradiol and Levonorgestrel.
Time frame: Up to Day 5 in Period 1 and between Days 14-21 in Period 2
Time to Cmax (Tmax) of Ethinyl Estradiol and Levonorgestrel
Tmax of Ethinyl Estradiol and Levonorgestrel.
Time frame: Up to Day 5 in Period 1 and between Days 14-21 in Period 2
Terminal Phase Elimination Rate Constant (β) of Ethinyl Estradiol and Levonorgestrel
β of Ethinyl Estradiol and Levonorgestrel.
Time frame: Up to Day 5 in Period 1 and between Days 14-21 in Period 2
Terminal Phase Elimination Half-Life (t1/2) of Ethinyl Estradiol and Levonorgestrel
t1/2 of Ethinyl Estradiol and Levonorgestrel.
Time frame: Up to Day 5 in Period 1 and between Days 14-21 in Period 2
Area Under the Plasma Concentration-Time Curve From Time 0 to Time of Last Measurable Concentration (AUCt) of Ethinyl Estradiol and Levonorgestrel
AUCt of Ethinyl Estradiol and Levonorgestrel.
Time frame: Up to Day 5 in Period 1 and between Days 14-21 in Period 2
Area Under the Plasma Concentration-Time Curve From Time 0 to Infinite Time (AUCinf) of Ethinyl Estradiol and Levonorgestrel
AUCinf of Ethinyl Estradiol and Levonorgestrel.
Time frame: Up to Day 5 in Period 1 and between Days 14-21 in Period 2
Number of Participants with Adverse Events (AEs)
An AE is defined as any untoward medical occurrence in a patient or clinical investigation in which a participant is administered a pharmaceutical product which does not necessarily have a causal relationship with this treatment.
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Time frame: Up to Approximately 82 Days