Tirzepatide is one of the new medications for the treatment of obesity. In clinical research people treated with Tirzepatide have weight loss up to 21%. But there is only a little bit of research showing the effect of Tirzepatide in clinical practice. In this retrospective observational study the investigators will evaluate the effectiveness of tirzepatide in routine clinical practice among adults with obesity in the Netherlands.The main questions it aims to answer are: * How much weight do patients lose after six months of treatment with tirzepatide combined with lifestyle coaching? * How is the medication dosed in daily practice? Researchers will use data from electronic health records of patients in multiple outpatient locations of the Dutch Obesity Clinic (NOK, Nederlandse Obesitas Kliniek).
Study Type
OBSERVATIONAL
Enrollment
1,700
Initiating treatment with tirzepatide
NOK clinics
Amsterdam, Netherlands
NOK clinics
Arnhem, Netherlands
NOK clinics
Beverwijk, Netherlands
NOK clinics
Gouda, Netherlands
NOK clinics
Heerlen, Netherlands
NOK clinics
Hoogeveen, Netherlands
NOK clinics
Nieuwegein, Netherlands
NOK clinics
Terneuzen, Netherlands
NOK clinics
The Hague, Netherlands
NOK clinics
Venlo, Netherlands
Weight change
%TWL= (start weight - 6 month weight/baseline weight)\*100%
Time frame: Baseline-6 months
Changes in body composition
Fat percentage (FP) and fat free mass (FFM)
Time frame: Basline-6 months
Demographic and clinical characteristics
* Age * Gender * Treatment location * Obesity associated diseases: hypertension, dyslipidaemia, sleep apnoea and osteoarthritis * Previous lifestyle treatment for obesity
Time frame: Baseline
Weight loss by maintenance dose
Maintenance dose (10mg and 15mg)
Time frame: Baseline-6 months
Tirzepatide dosing patterns
Including the initial prescribed dose and subsequent dose escalations throughout the treatment course
Time frame: Baseline-6 months
Weigth
in kilograms (kg)
Time frame: Baseline-6 months
Height
in centimeters (cm)
Time frame: Baseline-6 months
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