Exploring the Influence of Glucagon-like Peptide -1 (GLP-1) Medications on Food Cravings, Food Selection, and Food Intake Following Exposure to Food Advertisements

N/ANot Yet RecruitingNCT07505134

Penn State University50 enrolled

Overview

The purpose of this randomized control trial is to compare how food cravings, food selection, and food consumption change in response to frequent food advertisements compared to non-food advertisements in adults taking GLP-1 (weight loss) medications. The primary question we aim to answer is: do GLP-1 medications reduce an individual's vulnerability to external triggers that drive food cravings and consumption? Participants will: * report daily food consumption for a total of 10 days, * receive eight daily prompts to view food or non-food related advertisements, and respond to a short 9-question survey for 7 days, * answer several questionnaires, * and complete two in-person visits to complete a virtual reality food selection task.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

GLP - 1

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults (18+) with overweight or obesity (BMI \>25 kg/m2) * On an injectable form of tirzepatide GLP-1 medication at a minimum dose of 7.5 mg, taking it as prescribed by their doctor * Not currently taking an incretin-based medication at baseline other than the GLP-1 medication * Fluent in English Exclusion Criteria: * Do not have consistent access to a smart phone that can access the study software * Diagnosed with cognitive or physical disability or epilepsy * Adults taking a compound GLP-1

Outcomes

Primary Outcomes

Mean food cue reactivity scores in the afternoon

Average scores of craving levels for each group following afternoon advertisement viewing sessions

Time frame: 7-day period of all afternoon survey responses

Mean food cue reactivity scores in the morning

Average scores of craving levels for each group following morning advertisement viewing sessions

Time frame: 7-day period of all morning survey responses

Mean food cue reactivity scores in the evening

Average scores of craving levels for each group following evening advertisement viewing sessions

Time frame: 7-day period of all evening survey responses

Mean food cue reactivity scores overall

Average scores of craving levels for each group over all viewing sessions

Time frame: 7-day period of all survey responses

Energy density of consumed foods

The energy density profile of foods consumed each day

Time frame: 7 days

Secondary Outcomes

Change from baseline in energy density of foods selected in the virtual buffet

Time frame: Baseline and 7 days

Changes in food noise since being on medication questionnaire

Questionnaire assessing various aspects of food noise at present compared to before the medication

Time frame: Baseline

Changes in reasons for purchasing foods questionnaire

A questionnaire that assesses how five factors impact purchasing choices, and how the main factors have changed between prior to starting the medication and after.

Time frame: Baseline

Individual Food Cue Responsiveness--Trait

Time frame: Baseline

Change in brand familiarity, liking, and/or craving

A questionnaire that measures the familiarity, liking, and craving of each brand the participant will be exposed to (baseline) or has been exposed to (after intervention).

Time frame: Baseline and 7 days