This study looks at how a study medicine called PF-08653944 affects how quickly the stomach empties food after eating. It is being done in adults who are overweight or have obesity. Participants will receive the study medicine for a short period, and doctors will measure how the medicine moves through the stomach and monitor safety. The goal is to better understand how this medicine works in the body and to check for any side effects. The information from this study may help researchers plan future studies of this medicine.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
22
Subcutaneous Injection
Oral suspension
Pfizer Clinical Research Unit - New Haven
New Haven, Connecticut, United States
Acetaminophen Pharmacokinetic (PK) Parameters: Maximum observed plasma concentration (Cmax)
To assess the effect of multiple SC doses of PF-08653944 on the plasma PK profile of acetaminophen, a marker for gastric emptying, in healthy adult participants with overweight or obesity.
Time frame: Day 1 pre-dose through approximately 11 Weeks after last dose of study intervention.
Acetaminophen PK parameters: Area under the plasma concentration (AUC)
To assess the effect of multiple SC doses of PF-08653944 on the plasma PK profile of acetaminophen, a marker for gastric emptying, in healthy adult participants with overweight or obesity.
Time frame: Day 1 pre-dose through approximately 11 Weeks after last dose of study intervention.
Acetaminophen PK parameters: Time to Maximum concentration (Tmax)
Time frame: Day 1 pre-dose through approximately 11 Weeks after last dose of study intervention.
Number of participants with Treatment Emergent Adverse Events (TEAEs)
Time frame: First dose through study completion, approximately 11 Weeks post last dose.
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