The Role of Urinary RhoA, NGF, and BDNF Levels in Overactive Bladder and Vitamin D Deficiency

N/ANot Yet RecruitingNCT07513363

Tarik Emre Sener52 enrolled

Overview

The primary aim of this study is to evaluate the role of three specific urinary proteins-RhoA, Nerve Growth Factor (NGF), and Brain-Derived Neurotrophic Factor (BDNF)-as potential biomarkers for the diagnosis and follow-up of children aged 4-18 diagnosed with Overactive Bladder (OAB) and Vitamin D deficiency.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Overactive Bladder Vitamin D Deficiency

Interventions

UrotherapyBEHAVIORAL

Diagnosis and first-line treatment (urotherapy) will be conducted per European Association of Urology (EAU) guidelines.

Eligibility

Sex: ALLMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Children aged 4-18 years presenting with active OAB symptoms (frequency, urgency) Exclusion Criteria: * Neurological diseases * Malignancy * Active urinary tract infections * Anatomical bladder anomalies * History of prior OAB treatment/urological surgery.

Locations (1)

Marmara University School of Medicine Urology Department

Pendik, Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Changes in Urinary Biomarker Levels: * Quantitative measurement of urinary RhoA, NGF (Nerve Growth Factor), and BDNF (Brain-Derived Neurotrophic Factor) levels using the ELISA method.

Time frame: One year

Secondary Outcomes

Clinical Symptom Improvement: * Reduction in LUTS (Lower Urinary Tract Symptoms) based on standardized voiding dysfunction symptom scores.

Time frame: One year

Central Contacts

Hamza Tunahan Midilli

CONTACT

905449695848 hamzamidilli@gmail.com

Data from ClinicalTrials.gov

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