This study aims to evaluate the possible efficacy and safety of nicorandil as anti-inflammatory in managing patients with active rheumatoid arthritis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
46
Nicorandil 5 MG Oral Tablet
Tanta university
Tanta, Gharbia Governorate, Egypt
RECRUITINGchange in 28-joint count Disease Activity Score (DAS28) using C- reactive protein level (CRP)
Calculation of 28-joint count Disease Activity Score (DAS28) using C- reactive protein level (CRP) where: Remission: \< 2.6. Low Disease Activity (LDA): ≤ 3.2. Moderate Disease Activity (MDA): 3.2 - 5.1. High Disease Activity (HDA): \> 5.1
Time frame: 3 months
change in Multidimensional Health Assessment Questionnaire (MDHAQ) scores.
Before and 3 months after the intervention, the validated Arabic Multidimensional Health Assessment Questionnaire (MDHAQ) Physical Function: Assessed through 10 activities, scored 0-3 (without difficulty=0, some=1, much=2, unable=3), with higher scores indicating worse function
Time frame: 3 months
The change in the serum level of 8-hydroxydeoxyguanosine (8-OHdG) at baseline and after 3 months.
Blood samples will be collected at baseline and after 3 months
Time frame: 3 months
The change in the serum level of Interleukin 6 (IL-6) at baseline and after 3 months .
Blood samples will be collected at baseline and after 3 months
Time frame: 3 months
The change in the serum level of C- reactive protein (CRP) at baseline and after 3 months.
Blood samples will be collected at baseline and after 3 months
Time frame: 3 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.