Ventricular arrhythmias are a serious complication of myocardial infarction. The aim of this study is to provide reliable data on the management and mortality associated with ventricular arrhythmia in the setting of acute myocardial infarction.
Ventricular arrhythmias remain a major complication during the acute phase of myocardial infarction. The 2022 European guidelines on ventricular arrhythmias recommend implantable cardioverter-defibrillator (ICD) placement for secondary prevention when ventricular fibrillation occurs ≥ 48 hours after the infarct. Yet this recommendation rests on limited evidence. We therefore conduct a multicentre retrospective study to characterise the clinical profile, management, and prognosis of sustained ventricular arrhythmias (ventricular tachycardia and ventricular fibrillation) arising in the acute myocardial infarction setting. The primary objective of this study is to evaluate post-discharge mortality in patients who develop an arrhythmia either within 48 hours of, or more than 48 hours after, an acute myocardial infarction. Sensitivity analyses will further examine outcomes according to the arrhythmia subtype (ventricular fibrillation vs ventricular tachycardia), the presence of concomitant heart failure, and the myocardial-infarction phenotype (STEMI vs NSTEMI).
Study Type
OBSERVATIONAL
Enrollment
500
University hospital of Caen
Caen, France
RECRUITINGUniversity hospital of Dijon
Dijon, France
RECRUITINGUniversity hospital of Grenoble
Grenoble, France
Post-discharge mortality
Time frame: through study completion, an average of 2 years
Baseline demographic and clinical characteristics at inclusion
This outcome is the characterization of the study population at baseline, including demographic, and clinical-related variables collected at the time of myocardial infarction.
Time frame: At baseline
Number of participants fot each type of myocardial infarction
Includes revascularization strategy and other therapeutic management measures implemented during the index hospitalization.
Time frame: At baseline
Number of participants with each ventricular arrhythmia characteristic and management strategy during index hospitalization
Descriptive summary of ventricular arrhythmia presentation and in-hospital management, including arrhythmia type, timing of occurrence, recurrence, and therapeutic interventions.
Time frame: At baseline
In-hospital mortality
proportion of patients who die during their hospital stay, before discharge
Time frame: From admission until the date of death or hospital discharge, whichever came first, assessed up to 28 days
Number of participants with wearable cardioverter-defibrillator utilization
Time frame: At baseline
Rate of recurrent myocardial infarction after hospital discharge
Time frame: through study completion, an average of 2 years
Rate of recurrent ventricular arrhythmias after hospital discharge
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Hopital Européen Georges Pompidou
Paris, France
RECRUITINGHospital of Pau
Pau, France
RECRUITINGUniversity hospital of Poitiers
Poitiers, France
RECRUITINGUniversity hospital of Saint Etienne
Saint-Etienne, France
RECRUITINGUniversity hospital of Tours
Tours, France
RECRUITINGTime frame: through study completion, an average of 2 years
Rate of defibrillator implantation during hospitalization and after hospital discharge
Time frame: through study completion, an average of 2 years
Number of participants, incidence, characteristics, and management of electrical storms
Time frame: At baseline