Acute Effect of Polyphenols Supplementation on Endothelial Function and Exercise Related Markers, in Physically Active Healthy Volunteers.

N/AActive Not RecruitingNCT07518758

Nexira38 enrolled

Overview

To evaluate the effect of acute polyphenols supplementation on vasodilation and related markers along with exercise related markers (notably performance, respiratory exchanges, perceived exertion), before, during and after a hypoxic moderate-intensity exercise in healthy recreative volunteers.

Exercise session is an ergometer cycling workout performed under hypoxia condition equivalent to 3000 meters of altitude. Exercise session is composed of a warmup period followed by 20 minutes of cycling starting at 60% of individual maximal aerobic power.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

Conditions

Vasodilation Exercise Healthy Adults

Interventions

Oral administrationDIETARY_SUPPLEMENT

2 capsules the day before and 2 capsules 2 hours before the exercise session

Eligibility

Sex: ALLMin age: 35 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI \< 27 * Abdominal circumference \< 94 cm * Stable exercise training program during past 2 months Exclusion Criteria: * Total weekly exercise sessions \< 4 hours OR \> 8 hours * Drug or supplement intake during past one month that could interfere with study parameters * Volunteer suffering of respiratory or pulmonary condition * Volunteer exposed to an altitude \> 2000 meters during at least 3 weeks for the past 6 months.

Locations (1)

Centre expertise de la performance Gilles Cometti

Dijon, France

Outcomes

Primary Outcomes

Flow mediated dilation (FMD ; %)

Comparison of brachial artery diameter measured by ultrasound, before and after distal cuff-occlusion

Time frame: Before the exercise session (at rest under normoxia and hypoxia conditions)

Secondary Outcomes

Fraction exhaled nitric oxyde (FeNO ; ppb)

Exhaled breath, quantified by electrochemical analyzer

Time frame: Before the exercise session (at rest under normoxia and hypoxia conditions) / After the exercise session (under normoxia condition).

Oximetry (SpO2, %)

finger captation

Time frame: Before the exercise session (at rest under normoxia and hypoxia conditions) / During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition)

Muscular oximetry (SmO2, saturation index)

Rectus femoris muscle captation

Time frame: During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition)

Maximal power and Total work (watt)

Ergometer

Time frame: During exercise session (5 minutes intervals)

Respiratory gas exchanges (VO2, VCO2 ; mL/min/kg))

Gas mask

Time frame: Before the exercise session (at rest under normoxia and hypoxia conditions) / During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition)

Respiratory exchange ratio (RER)

Gas mask

Time frame: Before the exercise session (at rest under normoxia and hypoxia conditions) / During exercise session (5 minutes intervals) / After the exercise session (under normoxia condition)

Data from ClinicalTrials.gov

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