The purpose of this clinical study is to find out if NNC0662-0419 is safe and effective to be taken together with other medicines, like birth control pills, and emptying of the stomach in women not able to become pregnant living with overweight or obesity. There are 3 study treatments in this study, participants will get all of the treatments, NNC0662-0419 the treatment being tested, Altavera a type of birth control pill, Acetaminophen a common type of mild painkiller.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
45
Once-weekly subcutaneous NNC0662-0419 will be administered using a pen injector
An oral contraceptive Altavera \[levonorgestrel (LN) 0.15 milligram (mg) and ethinyl estradiol (EE) 0.03 mg\] will be administered orally.
A single dose of acetaminophen will be administered orally.
Altasciences Clinical Kansas, Inc.
Overland Park, Kansas, United States
Area under curve (AUC) 0-24 h, EE, steady state (SS): The area under the EE plasma concentration-time curve (pre-dose to 24 hours post-dose)
Measured as picograms per milliliter (h\*pg/mL)
Time frame: Day 8 and 1 day after last NNC0662-0419 dose
AUC0-24h, LN, SS: The area under the LN plasma concentration-time curve (pre-dose to 24 hours post-dose)
Measured as h\*pg/mL
Time frame: Day 8 and 1 day after last NNC0662-0419 dose
Maximum concentration (Cmax), EE, SS: Maximum observed EE plasma concentration (pre-dose to 24 hours post-dose)
Measured as pg/mL
Time frame: Day 8 and 1 day after last NNC0662-0419 dose
Cmax, LN, SS: Maximum observed LN plasma concentration (pre-dose to 24 hours post-dose)
Measured as pg/mL
Time frame: Day 8 and 1 day after last NNC0662-0419 dose
AUC0-60min, para: The area under the paracetamol plasma concentration-time curve (pre-dose to 60 minutes post-dose) following a standardised meal
Measured as microgram per milliliter (h\*μg/mL)
Time frame: Day 1 and 1 day after 3rd NNC0662-0419 dose on highest dose step
AUC0-300min, para: The area under the paracetamol plasma concentration-time curve (pre-dose to 300 minutes post-dose) following a standardised meal
Measured as h\*μg/mL
Time frame: Day 1 and 1 day after 3rd NNC0662-0419 dose on highest dose step
Cmax, para; Maximum observed paracetamol plasma concentration (pre-dose to 300 minutes post-dose) following a standardised meal
Measured as μg/mL
Time frame: Day 1 and 1 day after 3rd NNC0662-0419 dose on highest dose step
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