Mechanisms of Cannabidiol and Sleep in the Context of Alcohol Use

Inclusion Criteria: * Able to provide informed consent * Self reported poor sleep quality (PSQI score \>5) * Hazardous or harmful levels of alcohol consumption (MINI AUD score ≧2) * No current moderate or severe alcohol withdrawal symptoms (CIWA-Ar) * For female participants of childbearing potential: Not pregnant or lactating at the time of study enrollment or trying to become pregnant as confirmed by urine preg. Lack of childbearing potential confirmed by a history of amenorrhea for at least 12 consecutive months and serum FSH level within the laboratory's reference range for postmenopausal females OR documented bilateral oophorectomy and/or hysterectomy * For female participants of childbearing potential: Agree to use a highly effective contraception method (i.e., a method with a failure rate of less than 1 percent per year when used consistently and correctly) starting at least five days before you begin the study and continuing for full participation. * No current use of sleep medications including CBD in the last 90 days * No history of complicated alcohol withdrawal (i.e., seizure, delirium tremens, or alcohol hallucinosis). * No current or past 6 months active suicidal ideation or suicidal behavior * No current diagnosis, or family history of diagnosis, of psychosis; current major psychiatric illness, such as bipolar disorder, major depression, or schizophrenia * No current cannabis use disorder (MINI SUD for cannabis score ≧2) * History of previous exposure to guaiol through CBD or other cannabis product Exclusion Criteria: * Current use of anti-epileptic medications (e.g., clobazam, sodium valproate, lamotrigine) * Greater than low risk for obstructive sleep apnea (STOP-BANG \<=4 or Moderate or greater risk as calculated by Nox Noxturnal Software from baseline PSG data) * Current use of medications known to have major interactions with Epidiolex (e.g., brexanolone, buprenorphine, colchicine, esketamine, fezolinetant, ketamine, leflunomide, levoketoconazole, levomethadyl acetate, lomitapide, mipomersen, morphine, pexidartinib, pralsetinib, propoxyphene, relugolix, sodium oxybate, teriflunomide, and venetoclax) * Current use of anti-psychotic medications * Current use of potent CYP2C19 or CYP3A4 inducers (e.g., Rifampin, apalutamide, carbamazepine, enzalutamide, ivosidenib9, lumacaftor, ivacaftor, phenytoin, St. John's wort, Fosphenytoin, Mitotane, Phenobarbital, Primidone) * History of hypersensitivity reactions to cannabidiol * Liver function test (Alanine transaminase \[ALT\] and Aspartate transaminase \[AST\]) levels ≥2x the upper normal limits at baseline * Moderate or severe liver disease * Allergy or aversion to gelatin (softgels contain porcine gelatin) * Report of illegal drug use (e.g., cocaine, methamphetamine) in the past 90 days or positive screening on urine toxicology test at Baseline visit. * Uncontrolled hypertension * Blood pressure findings concerning for moderate or severe alcohol withdrawal at baseline * Abnormal resting heart rate, defined as \<60 bpm or \>100 bpm at baseline