Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention

Inclusion Criteria: * Adult at least 18 years of age * Lower or Moderate Risk score on one or more substance use types on National Institute on Drug Abuse (NIDA)-Modified Alcohol, Smoking, and Substance Use Involvement Test (ASSIST). Participants may also endorse alcohol use in conjunction with substance use as indicated by an Alcohol Use Disorder Identification Test-Concise (AUDIT-C) score of Moderate Risk. Exclusion Criteria: * A priori participant request for participation * Concurrently enrolled in other study of substance use disorder prevention * Prisoner at time of enrollment * Known to be pregnant at time of enrollment * Past substance use disorder or substance use treatment * High risk score for one or more substances on the NIDA-Modified ASSIST or problematic alcohol use alone