This clinical study aims to determine whether taking two different doses of collagen-derived peptides for three months improves facial skin barrier integrity in women with dry, sensitive skin, compared with a placebo.
This study is designed to evaluate whether daily supplementation with collagen-derived peptides can improve the skin barrier of the face in women who have dry and sensitive skin. Participants will receive one of two different concentrations of collagen-derived peptides or a placebo, and the effects will be assessed after three months of treatment. The main goal is to compare the two active supplement doses against placebo to see if collagen peptides help strengthen or restore skin barrier integrity. The secondary objectives are to assess the impact of both concentrations on: * skin barrier integrity at two anatomical sites (face and leg) at T1, T2 and T3 (Tewameter®); * skin hydration at two anatomical sites (face and leg) at T1, T2 and T3 (Corneometer®); * skin barrier resistance (leg) after 10 strippings at T2 and T3 (Tewameter®); * skin barrier permeability (leg) at T2 and T3 (Caffeine penetration assay); * skin elasticity at two anatomical sites (face and leg) at T1, T2 and T3 (Cutometer®); * skin pH (face) at T1, T2 and T3 (pH-Meter®); * crow's feet wrinkles and fine lines at T1, T2 and T3 (PRIMOS®); * dermal thickness (Face) at T1, T2 and T3 (Dermscan®); * clinical signs (dryness, roughness, redness) at T1, T2 and T3 (clinical assessments); * subjective symptoms (tightness, itching, burning sensation) at T1, T2 and T3 (subject evaluation); * ceramide levels and other skin lipids (leg) at T2 and T3 (D-squame®); * ceramide levels and other skin lipids (face) at T3 (D-squame®); * participant perceived efficacy (Self-assessment questionnaire) at T1, T2 and T3; * safety at an ongoing basis (Adverse Event reporting).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
75
This product is going to be concentrated at 2000mg
This product is going to be concentrated at 5000mg
This product is going to be flavoured water
CPCAD - Centre Pharmacologie Clinique Appliqué à la Dermatologie, CHU Nice
Nice, France
RECRUITINGChange in Facial Skin Barrier Integrity Measured by Tewameter After 3 Months of Supplementation
The primary objective of this study is to assess the effects of 2 concentrations of collagen-derived peptides, compared to a placebo, on facial skin barrier integrity using a Tewameter, after three months of daily supplementation in women with dry and sensitive skin.
Time frame: from baseline until the end of treatment at T3 months
Skin Barrier Integrity, Hydration on the Face and Leg measured with Ph meter and Corneometer
The secondary objectives are to assess the effects of both concentrations on: \- skin barrier integrity at two anatomical sites (on the face and leg) using the PH meter; \_ Hydration using the corneometer
Time frame: From the baseline until the end of the treatment at T3 Months
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