A study conducted to evaluate the effects of sodium profiling haemodialysis compared with conventional haemodialysis on hemodynamic tolerance and extravascular lung water in critically ill patients with AKI and shock.
A prospective comparative study was conducted on 120 ICU patients with AKI and shock and indicated for acute intermittent hemodialysis, divided into three groups of 40 patients each: Group 1: conventional hemodialysis, Group 2: linear sodium profiling, and Group 3: stepwise sodium profiling. Hemodynamic parameters, vasopressor requirements, lung ultrasound scores, and IVC measurements were assessed before, during, and after dialysis to evaluate the effects of sodium profiling haemodialysis compared with conventional haemodialysis on hemodynamic tolerance and extravascular lung water in critically ill patients with AKI and shock.
Study Type
OBSERVATIONAL
Enrollment
120
Fayoum University
Al Fayyum, Faiyum Governorate, Egypt
Mean Arterial Pressure (MAP) changes during the session
MAP is asessed pre dialysis, during dialysis and post dialysis to detect changes among the groups
Time frame: 2 to 3 hours
Vasopressor Requirement during the session
Vasopressor dose changes during the session among the groups
Time frame: 2 to 3 hours
Lung Ultrasound Score (LUS)
Changes in LUS Pre and Post-dialysis among the groups A score of \>15 generally suggests mild congestion, while values \>24 are considered indicative of moderate-to-severe pulmonary oedema or significantly increased EVLW.
Time frame: 4 to 6 hours
Ultrasonagraphic IVC Diameter
Changes in Ultrasonagraphic IVC Diameter pre and post-dialysis among the groups
Time frame: 4 to 6 hours
Ultrasonagraphic IVC Collapsibility
Changes in Ultrasonagraphic IVC Collapsibility pre and post-dialysis among the groups
Time frame: 4 to 6 hours
Dialysis Completion Rate
the ability to complete the session without haemodynamic instability
Time frame: 2 to 3 hours
Length of ICU Stay
Length of ICU Stay among the groups
Time frame: 4 to 15 days
Mortality
short term Mortality during ICU stay
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Time frame: 4 to 15 days
Laboratory findings
Changes in serum sodium, Potassium, blood gases, urea and creatinine pre and post-dialysis among the groups
Time frame: 6 to 12 hours