Analysis of Influencing Factors for the Development of PTSD in Emergency Department Trauma Patients

N/ANot Yet RecruitingNCT07530432

The First Affiliated Hospital of Air Force Medicial University250 enrolled

Overview

The goal of this observational study is to learn about the long-term effects of key factors such as cognitive flexibility, social support, and physiological stress on the occurrence of Post-Traumatic Stress Disorder (PTSD) in adult trauma patients treated in the emergency department. The main question it aims to answer is: Among emergency department patients who have experienced major trauma, can factors such as early post-trauma cognitive flexibility, level of social support, inflammatory markers, and trauma severity predict the development of PTSD within 6 months? Participants will complete a series of online questionnaires and clinical assessments at baseline, 1 month, 3 months, and 6 months after the traumatic event.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Trauma Patients PTSD

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 18 and 65 years old (inclusive); * Experienced a life-threatening major traumatic event, clearly diagnosed by a clinician; * The patient is able to communicate normally with medical staff through language; * The subject is fully informed and voluntarily signs the informed consent form. Exclusion Criteria: * History of psychiatric disorders or current use of psychotropic medications; * Pre-existing cognitive impairment (e.g., dementia, Alzheimer's disease); * Terminal illnesses (such as advanced malignant tumors, end-stage organ failure, advanced neurological diseases, or any other condition judged by the attending physician to have a life expectancy of less than 6 months); * Inability to cooperate with follow-up.

Outcomes

Primary Outcomes

PTSD Incidence as Assessed by the PTSD Checklist for DSM-5 (PCL-5)

Number of participants with a total score ≥33 on the PCL-5 (range 0-80, higher scores indicate more severe PTSD symptoms) at 6 months after the traumatic event, indicating probable post-traumatic stress disorder (PTSD).

Time frame: 6 months post-trauma

Secondary Outcomes

Association of Sociodemographic, Trauma-Related, and Psychosocial Factors with PTSD Status

Odds ratios (ORs) and 95% confidence intervals for the association of each candidate factor (e.g., age, sex, injury severity score \[ISS\], social support \[SSRS score\], anxiety/depression \[HADS score\], cognitive flexibility \[CFI score\], inflammatory biomarkers \[IL-6, CRP\]) with probable PTSD status at 6 months, as determined by multivariable logistic regression.

Time frame: Baselin and 6 months post-trauma