The goal of this clinical trials is to learn about the effect of taking Prodentis on a long term basis following periodontal therapy. The main question it aims to answer is 1\. what is the effect of long-term consumption of Prodentis on regulating periodontal health and systemic immune-response, when compare to only taking it for 3 months post RSD?
Following root surface debridement (RSD), subjects in the control group (group NP) will be instructed to take Prodentis® twice/day immediately for 3 months only then continue 3 monthly review until month 12th. For subjects in the test group (group OP), following RSD, they will be instructed to take Prodentis® twice/day immediately for 3 months then continue Prodentis® once a day until month 12th. They will be reviewed 3 monthly.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
20
Non-surgical periodontal therapy
Universiti Malaya
Kuala Lumpur, Kuala Lumpur, Malaysia
RECRUITINGPeriodontal pocket depths
UNC-15 probe will be used to measure this outcome
Time frame: Baseline, 3 months, 6 months and 1 year
Biomarkers from Serum and Saliva
Serum and saliva will be collected to measure the levels of IL-6 and IL-10
Time frame: The collection of saliva and serum will be done at baseline, 3 month and 6 months post RSD, and finally at 12 month.
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