Study to Evaluate the Efficacy and Safety of Fexuprazan in Prevention of NSAIDs Induced Peptic Ulcer

Inclusion Criteria: 1. Male and female adults aged ≥ 19 years at the time of informed consent 2. Subjects who are diagnosed with musculoskeletal disease at screening and require continued treatment with NSAIDs for at least 24 weeks 3. Subjects with at least one of the following risk factors for ulcer development at screening. 4. Subjects who have no gastric or duodenal mucosal break or have ulcer in the scarring stage based on the EGD result at screening. Exclusion Criteria: 1. Subjects with esophagitis, gastroesophageal varix, esophagus, Barrett's esophagus, acute gastrointestinal bleeding and else based on the screening EGD results. 2. Subjects who have undergone gastroduodenal surgery or total small bowel resection 3. Subjects with history of clinically significant disease of hepatic, renal, nervous, pulmonary, endocrine, hemato-oncologic, cardiovascular or urinary system 4. Subjects who have had a malignant tumor in the last 5 years 5. Subjects who history of hypersensitivity to the IP ingredients, aspirin and NSAIDs