Fecal Microbiome Signature of Multi-Strain Probiotics Supplementation in Children and Adolescents With Inflammatory Bowel Disease

Inclusion Criteria: * Signed informed consent * Diagnosis of inflammatory bowel disease according to actual guidelines (Porto Criteria) * General good health * Ability to understand and follow study procedures and understand informed consent * Age 5 -18 years * No probiotic therapy 4 weeks before entering into the study. Exclusion Criteria: * Participation in other clinical studies interfering with study procedures. * Inability or contraindications to undergo the investigated intervention * Severe or acute flare of disease (for UC PUCAI score ≥35, for CD wPCDAI \>40) * Treatment escalation within last 4 weeks for uncontrolled disease. * Antibiotic or probiotic therapy within the last 4 weeks.