The objective of this study is to investigate "clinically" the effectiveness of Oleanolic acid based intracanal medicament compared to the commonly used intracanal medicaments (Calcium hydroxide and Ledermix) on the levels of bacteria in root canals and inflammatory cytokines in the periradicular tissues of teeth with apical periodontitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
36
Root canal treatments with administration of intracanal medicaments
Mansoura University
Al Mansurah, Dakahlia Governorate, Egypt
Relief of signs and symptoms of apical periodontitis
Absence of discomfort with percussion, Absence of inflammatory exudate from the root canal.
Time frame: 1 Week
Decrease in bacterial count within the root canal.
A sample will be taken from the canal to assess the decrease in bacterial count inside the root canal by the effect of intracanal medicament.
Time frame: 1 week
Decrease in interleukin TNF-alpha, IL-1 Beta and PG-E2 in the periapical tissues
A sample will be taken from the periapical region to detect the effect of the intracanal medicaments in reducing inflammation and promoting healing in the periapical region.
Time frame: 1 week
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