Femoroacetabular impingement syndrome is increasingly recognized as a contributor to cartilage injury and early hip osteoarthritis. Both structured conservative care and arthroscopic surgery can improve pain and function, but a major unresolved clinical problem is deciding who should continue conservative care and who should escalate to surgery, and when. Evidence indicates that shorter symptom duration before surgery is associated with better long-term improvement, meaning delays may reduce the chance of achieving meaningful recovery. Current decision-making still depends largely on static imaging and passive clinical examination, which do not capture the dynamic, movement-related nature of the condition, while advanced three-dimensional imaging and laboratory motion analysis are not practical for routine clinical monitoring. This study aims to address this gap by developing and validating feasible, clinic-ready dynamic assessment methods and integrating weight-bearing pelvic and spinal alignment with three-dimensional hip modeling to support more objective, individualized, and timely treatment decisions.
The escalating socioeconomic burden of hip osteoarthritis has driven a strategic shift toward earlier, joint-preserving interventions. Over the past two decades, femoroacetabular impingement syndrome (FAIS) has been increasingly recognized as a key contributor to cartilage injury and the development of early osteoarthritis. This recognition has not only led to the wider adoption of surgical interventions but also fueled significant advances in arthroscopic management. Yet, despite these developments, a central clinical challenge remains: determining which patients will benefit from prolonged conservative care and which require timely surgical care to optimize outcomes. Indeed, several randomized controlled trials have compared arthroscopy with conservative treatment, consistently showing that both approaches improve pain and function. Arthroscopy has demonstrated reliable short- to mid-term gains in patient-reported outcomes, while rehabilitation and conservative management also enable a substantial proportion of patients to achieve meaningful improvement. Although, these findings highlight the value of both strategies, the optimal sequence and timing of non-surgical and surgical care remains unknown. Emerging literature makes it clear that the timing of surgical intervention is a critical factor in hip preservation. A recent multi-level systematic review showed that shorter symptom duration before arthroscopy is consistently associated with superior outcomes, including greater functional gains, higher rates of achieving clinically meaningful thresholds, and a lower risk of persistent pain. Similarly, a 10-year longitudinal study demonstrated that durable improvements are most likely when surgery is performed earlier in the disease course, whereas delays reduce the likelihood of achieving Minimal Clinically Important Difference (MCID) and Patient Acceptable Symptom State (PASS) thresholds. Together, these findings establish timing as a critical determinant of long-term outcomes and underscore the pressing need for dynamic, clinic-ready tools that can guide the transition from rehabilitation to surgery in young adults with FAIS. However, current diagnosis and treatment planning for FAIS relies heavily on static imaging and passive clinical examination, which cannot capture the dynamic, movement-related nature of the condition. Advanced biomechanical studies have shown that patients with FAIS differ from controls not only in femoral and spinopelvic morphology\[8\] but also in movement strategies during hip-hinging tasks such as deep squats. While these insights have enhanced our understanding of FAIS, their clinical translation remains very limited due to ethical and practical limitations. Firstly, while CT-based 3D imaging can provide detailed morphological assessment, its relatively high radiation dose makes it unsuitable for repeated monitoring in young adults. Similarly, 3D motion analysis has demonstrated important alterations in kinematics, yet the cost, time demands, and need for technical expertise restrict its use to research laboratories. As a result, there are still no feasible, clinic-ready protocols that adequately capture the dynamic nature of FAIS for everyday decision-making. Consequently, treatment planning in young adults, including the above combination of non-surgical and surgical care, often depends on subjective judgment and limited examination factors, which increases the risk of suboptimal care. The central challenge, therefore, is not whether FAIS should be managed conservatively or surgically, but how to effectively determine which patients are best suited for each pathway and at what point in their care. As hip preservation moves toward preventive strategies and increasingly refined arthroscopic techniques, developing practical, individualized and objective tools to support timely decision-making is essential. This project aims to directly address that need.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
60
Functional lateral x-ray scans will be obtained in three postures: standing, relaxed sitting, and deep flexed sitting. This previously validated protocol, provides posture-specific measures of spinopelvic alignment under physiological load and allows to integrate weight-bearing spinopelvic alignment into 3D hip coverage analysis. By extending imaging beyond a femur-centric perspective, this method better reflects the dynamic, multi-regional nature of FAIS.
A multi-echo Fast Field Echo (mFFE) MRI will be acquired to generate highcontrast, bone-like images without ionizing radiation. The imaging sequence can be readily implemented on standard 1.5T and 3T MRI scanners available at the collaborating sites. An in-house pipeline will enable automated 3D segmentation of the lumbar spine, pelvis, acetabulum, proximal femur and condyles.
Participants will complete markerless 3D motion capture during three hip-hinge tasks: deep squat, sumo squat, and Romanian deadlift (20% body weight). Lumbar, pelvic and hip movements will be measured in all three planes. Data will be recorded using two research-dedicated iPads running the movement tracking software.
In a subgroup of participants, during three hip-hinge tasks: deep squat, sumo squat, and Romanian deadlift (20% body weight). Lumbar, pelvic, and hip movements will be measured in all three planes using our validated marker-based 3D motion capture system.
Universitaire Ziekenhuizen KU Leuven
Leuven, Vlaams-Brabant, Belgium
Change in International Hip Outcome Tool-33 (iHOT-33)
The iHOT-33 questionnaire is a patient-reported questionnaire designed to measure the health-related quality of life in young, active patients with symptomatic hip disease. The questionnaire consists of 33 items divided into four main domains: 1. Symptoms and Functional Limitations; 2. Sports and Recreational Activities; 3. Job-Related Concerns; 4. Social, Emotional, and Lifestyle Concerns. The final score of this questionnaire ranges from 0 to 100, where 100 represents a perfect quality of life with no hip-related limitations, while 0 represents the highest level of disability.
Time frame: From enrollment to the end of the study, following a 12-month follow-up period
Changes in International Physical Activity Questionnaire (IPAQ)
The IPAQ (International Physical Activity Questionnaire) is a standardized tool used to estimate an individual's total physical activity and energy expenditure. The questionnaire asks you to recall your physical activity over the last 7 days. Based on the total score, individuals are categorized into three levels: 1.Low: Not meeting the criteria for the other categories (inactive). 2. Moderate: Roughly equivalent to 30 minutes of at least moderate-intensity activity on most days.3. High: Equivalent to about one hour of activity per day (or very high-intensity training).
Time frame: From enrollment to the end of the study, following a 12-month follow-up period
Change in Pain Catastrophizing Scale (PCS)
The PCS (Pain Catastrophizing Scale) is a tool designed to measure how a person thinks and feels about their pain. It consists of 13 statements describing different thoughts and feelings. Patients rate how much they experience these thoughts on a 5-point scale, from 0 (Not at all) to 4 (All the time). Patients with high PCS scores often experience higher pain intensity.
Time frame: From enrollment to the end of the study, following a 12-month follow-up period
Change in Tampa Scale for Kinesiophobia (TSK)
The Tampa Scale for Kinesiophobia (TSK) is a questionnaire used to measure a patient's fear of movement (kinesiophobia). The questionnaire consists of 17 items rated on a 4-point scale (from "Strongly Disagree" to "Strongly Agree"). Scores range from 17 to 68. A score of 37 or higher is generally considered "high," indicating that the person has significant fear that is likely interfering with their recovery.
Time frame: From enrollment to the end of the study, following a 12-month follow-up period
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