The goal of this clinical trial is to learn about the efficacy of using Bone Marrow Aspirate Concentrate (BMAC) during temporomandibular joint (TMJ) arthroscopy compared to standard arthroscopic procedures with corticosteroid (CS) injections in patients with pain (arthralgia) of the temporomandibular joint (TMJ) that has failed to respond to conservative treatment. The main question it aims to answer: Does BMAC injection reduce the amount of inflammation and structural damage in the TMJ? Researchers will compare BMAC injection to corticosteroid injections see if BMAC injection helps . Participants will : * Be randomized to receive either BMAC or CS injection during TMJ arthroscopy * Visit the clinic for 3 follow up visits over 6 months and answer questionnaires * have 2 MRIs of their jaw
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
20
Single dose injection of bone marrow fluid from the participant's anterior iliac crest (hip) into the TMJ area during arthroscopy.
Single dose injection of cortiosteroid into the TMJ area during arthroscopy.
Weill Cornell Medical College - NewYork-Presbyterian Hospital
New York, New York, United States
Change from Baseline in Kellenberger score at 6 Months.
Participant MRIs will be given a Kellenberger score of 0-13. A higher Kellenberger scores indicate a higher degree of inflammation and damage.
Time frame: Baseline; 6 months
Change in Maximum interincisal opening (MIO)
Distance measured on a ruler between the incisal edges in millimeters
Time frame: Baseline , Procedure, 3 weeks post-op, 3 months post-op, 6 months post-op
Change in Pain Scores
Pain on Visual analogue score. Zero is equivalent to no pain and 10 indicates the worst possible pain.
Time frame: Baseline, Procedure, 3 weeks post-op, 3 months post-op, 6 months post-op
Change in Jaw Functional Limitation Scale (JFLS) Score
JFLS is an 8 question survey on jaw functionality scored from 0 (no limitation) to 10 (severe limitation).
Time frame: Baseline, Procedure, 3 weeks post-op, 3 months post-op, 6 months post-op
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