Intra-Arterial Tirofiban After Complete Recanalization for Acute Intracranial Large-Vessel Occlusion

Inclusion Criteria: * 1\. Age ≥ 18 2. Last known well (LKW) to arterial puncture time within 0-24 hours 3. Preoperative imaging confirms anterior circulation large vessel occlusion: internal carotid artery (ICA) intracranial segment or middle cerebral artery (MCA) M1 or M2 trunk occlusion 4. Baseline NIHSS 6-25 5. Baseline ASPECTS ≥ 6 (CT or DWI) 6. Pre-stroke modified Rankin Scale (mRS) ≤ 1 7. After mechanical thrombectomy, eTICI 2c-3 complete recanalization achieved; or intraoperative imaging showing spontaneous recanalization to eTICI 2c-3 without further mechanical thrombectomy 8. Embolic occlusion: no residual fixed stenosis in the responsible vessel after thrombectomy 9. Participant or legal guardian has signed written informed consent Exclusion Criteria: * 1\. Pregnancy or breastfeeding 2. Active bleeding within the last month (e.g., gastrointestinal/urinary bleeding) or known severe bleeding tendency 3. Major underlying disease with life expectancy \< 6 months or judged by the investigator as unable to complete follow-up 4. Participation in other interventional clinical trials 5. Use of oral anticoagulants within 48 hours prior to symptom onset and INR \> 1.7; or use of direct oral anticoagulants and non-compliance with the institution's specified drug cessation/testing requirements 6. Platelet count \< 50×10\^9/L 7. Blood glucose \< 2.8 mmol/L or \> 22.2 mmol/L, unable to correct in a short time 8. Severe renal insufficiency (eGFR \< 30 mL/min/1.73m\^2 or Scr \> 2.5 mg/dL) 9. Systolic BP \> 185 mmHg or diastolic BP \> 110 mmHg, poorly controlled despite treatment 10. Imaging evidence of intracranial hemorrhage; or presence of intracranial aneurysm/arteriovenous malformation/obvious space-occupying brain tumors or high bleeding risk lesions; or bilateral acute cerebral infarction or multiple intracranial arterial occlusions 11. Intraoperative vascular rupture, dissection, extravasation of contrast agent, or other severe complications that require a change in standard anticoagulation strategy 12. Need for balloon angioplasty, permanent stent placement, or planned initiation of antiplatelet/anticoagulation therapy within 24 hours post-procedure 13. More than 3 attempts of thrombectomy or time from arterial puncture to recanalization \> 90 minutes (to reduce procedure-related injury and confounding factors) 14. Use of intravenous heparin bolus dose intraoperatively (except for heparinized saline wash) 15. Suspected embolic stroke from infection or infectious endocarditis 16. Severe allergy to contrast agents or tirofiban