In children allergic to egg, oral immunotherapy (OIT) with egg may accelerate that the children grow out of the food allergy. Children than have a positive oral food provocation with egg with a low threshold, will be offered to start OIT. This means that the child have to ingest a small amount of egg every day. Once a year, the child will undergo a new oral food provocation to investigate if the child is still allergic to egg or not. The age of the children at time of this acquired tolerance will be compared with a historical cohort of children with egg allergy.
The aim of the study is to investigate if OIT with egg white can accelerate tolerance to egg in infants with provocation-verified allergy to egg and with a low threshold. The study is non-randomised. Children fulfilling the inclusion criteria will be offered OIT. The children will undergo an oral provocation once a year to detect development of tolerance to egg. Age at tolerance acquisition will be compared with a histical cohort of aged-matched children with allergy to egg and with a similar threshold at the diagnostic provocation
Study Type
OBSERVATIONAL
Enrollment
40
The children have to ingest a small specified amount of egg white every day. The amount will gradually increase, as the child becomes more and more tolerant to egg
Percentage of children who develops tolerance to egg per year
Once a year the children will undergo an oral food provocation with egg to investigate if they have becomed tolerant to egg
Time frame: If the oral food provocation is negative (that is the child is still allergic to egg) the child will be re-provocated after 12 months. As long as the provocation is positive it will be repeated once a year for 5 years
specific IgE
Measurement of specific IgE to egg in the blood
Time frame: baseline and through study completion, an average of 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.