This multicenter study aims to evaluate clinical outcomes and optimize management strategies in patients with early colorectal cancer who undergo non-curative endoscopic resection. Patients with non-curative resection following endoscopic treatment will be enrolled across multiple centers and managed according to real-world clinical decisions, including additional surgery or surveillance. Baseline demographic, endoscopic, and pathological characteristics will be systematically collected. The primary objective is to compare recurrence and survival outcomes between different management strategies. Secondary objectives include identifying prognostic factors associated with recurrence and developing a risk stratification model to guide individualized treatment decisions. All participants will undergo standardized follow-up according to clinical guidelines. This study is expected to provide real-world evidence to refine risk assessment, reduce unnecessary surgery, and improve personalized management for patients with early colorectal cancer after non-curative endoscopic resection.
Study Type
OBSERVATIONAL
Enrollment
400
Additional surgical resection performed after non-curative endoscopic resection based on pathological risk factors and clinical indications.
Active surveillance with regular endoscopic and imaging follow-up without additional surgical intervention.
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China
RECRUITINGShenzhen Longgang District People's Hospital
Shenzhen, Guangdong, China
RECRUITINGThe Second Affiliated Hospital of Guangzhou Medical University
Haizhu, Guangzhou, China
RECRUITINGRecurrence-Free Survival
Time frame: Up to 2 years
Association Between High-Risk Pathological Factors and Recurrence
Time frame: Up to 2 years
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