Effectiveness of Serratiopeptidase After Mandibular Third Molar Surgery

Sharif Medical Research Center110 enrolled

Overview

This randomized controlled trial was conducted to compare the effect of serratiopeptidase versus no intervention on postoperative mouth opening, swelling, and trismus following surgical removal of mesioangular mandibular third molars.

A total of 110 patients undergoing surgical extraction of mesioangular mandibular third molars were randomly assigned into two groups. Group A received serratiopeptidase postoperatively, while Group B received no enzyme therapy. Mouth opening was measured postoperatively and compared between the two groups to assess the effectiveness of serratiopeptidase in reducing trismus and postoperative swelling.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

110

Conditions

Trismus

Interventions

SerratiopeptidaseDRUG

Serratiopeptidase was administered postoperatively following surgical removal of a mesioangular mandibular third molar as an adjunct to standard postoperative care to reduce postoperative pain, swelling, and inflammation.

Standard Postoperative CareOTHER

Routine postoperative management following surgical removal of a mesioangular mandibular third molar without serratiopeptidase, including prescribed analgesics, antibiotics if indicated, and postoperative instructions.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- Patients aged 18 to 40 years. Patients requiring surgical removal of a mesioangular impacted mandibular third molar. Patients who are systemically healthy (ASA I or II). Patients willing to participate and provide written informed consent. Patients who can comply with postoperative follow-up visits. Exclusion Criteria: * Patients with systemic diseases affecting healing (e.g., diabetes, immunocompromised state). Pregnant or lactating women. Patients with known allergy or hypersensitivity to serratiopeptidase. Patients on long-term anti-inflammatory or steroid medication. Presence of acute infection at the surgical site. Patients who have taken anti-inflammatory drugs within 48 hours before surgery.

Locations (1)

Sharif medical and dental college, jati umra.

Lahore, Punjab Province, Pakistan

Outcomes

Primary Outcomes

Postoperative Facial Swelling

Change in facial swelling measured using standardized facial measurements between fixed anatomical landmarks following surgical removal of a mesioangular mandibular third molar, comparing the serratiopeptidase group and the control group.

Time frame: Postoperative Day 1, Day 3, and Day 7

Data from ClinicalTrials.gov

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