This study aims to evaluate peak airway pressure and respiratory mechanics during pressure-regulated volume control (PRVC) ventilation in patients undergoing elective laparoscopic abdominal surgery. Pneumoperitoneum and patient positioning during laparoscopic procedures can significantly affect respiratory mechanics, including airway pressures and lung compliance. The study will assess changes in peak airway pressure, dynamic compliance, and other ventilatory parameters during different intraoperative phases. The findings are expected to provide insights into optimizing ventilatory strategies to improve patient safety and minimize ventilator-associated complications during laparoscopic surgery.
Laparoscopic abdominal surgery requires the creation of pneumoperitoneum, which increases intra-abdominal pressure and affects respiratory system mechanics. These changes can lead to increased peak airway pressure and reduced lung compliance, potentially increasing the risk of ventilator-induced lung injury. Pressure-regulated volume control (PRVC) ventilation is designed to deliver a set tidal volume with the lowest possible airway pressure by adjusting inspiratory pressure dynamically. However, its performance during laparoscopic procedures and its effect on respiratory mechanics require further evaluation. This prospective observational study will be conducted on adult patients undergoing elective laparoscopic abdominal surgery under general anesthesia. Standardized anesthesia and ventilation protocols will be applied. Respiratory parameters including peak airway pressure, tidal volume, respiratory rate, and dynamic compliance will be recorded at predefined time points: after induction, after pneumoperitoneum, and at steady-state intraoperative conditions. The primary outcome will be peak airway pressure. Secondary outcomes include dynamic compliance and other ventilatory parameters. The study aims to enhance understanding of respiratory mechanics during PRVC ventilation and support evidence-based optimization of intraoperative ventilation strategies.
Study Type
OBSERVATIONAL
Enrollment
52
Mechanical ventilation using pressure-regulated volume control mode applied as part of routine intraoperative anesthesia care. No experimental intervention is introduced.
SpecializedMedicalCenter
Riyadh, Saudi Arabia
RECRUITINGPeak Airway Pressure
Peak airway pressure (PIP) measured intraoperatively using the anesthesia workstation under standardized pressure-regulated volume control ventilation settings.
Time frame: At 0, 5, and 10 minutes intraoperatively
Dynamic Compliance
Dynamic lung compliance (Cdyn) measured intraoperatively using standard anesthesia monitoring at predefined time points.
Time frame: At 0, 5, and 10 minutes intraoperatively
Plateau Pressure
Plateau pressure (Pplat) measured during controlled ventilation using the anesthesia workstation.
Time frame: At 0, 5, and 10 minutes intraoperatively
End-tidal Carbon Dioxide
End-tidal carbon dioxide (EtCO2) measured continuously during mechanical ventilation.
Time frame: At 0, 5, and 10 minutes intraoperatively
Mean Airway Pressure
Mean airway pressure measured intraoperatively using the anesthesia workstation.
Time frame: At 0, 5, and 10 minutes intraoperatively
Oxygen Saturation
Peripheral oxygen saturation (SpO2) monitored continuously during surgery.
Time frame: At 0, 5, and 10 minutes intraoperatively
Heart Rate (beats/min)
Heart rate measured intraoperatively using standard monitoring
Time frame: At 0, 5, and 10 minutes intraoperatively
Mean Arterial Pressure (mmHg)
Mean arterial pressure measured intraoperatively using standard monitoring
Time frame: At 0, 5, and 10 minutes intraoperatively
Minute Ventilation
Minute ventilation recorded from the anesthesia workstation during controlled ventilation.
Time frame: At 0, 5, and 10 minutes intraoperatively
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