This study is a prospective observational cohort study conducted planned to include 40 patients with ARDS to assess the effect of different levels of PEEP titration on VExUS score and renal outcomes in patients with Acute Respiratory Distress Syndrome.
This study is a prospective observational cohort study conducted planned to include 40 patients with ARDS within 24 hours of onset and mechanically ventilated for more than 24 hours to assess the effect of different levels of PEEP titration on Venous Excess Ultrasound Score and renal outcomes in patients with Acute Respiratory Distress Syndrome.
Study Type
OBSERVATIONAL
Enrollment
40
The Venous Excess Ultrasound Score (VExUS) was calculated for each patient based on the assessment of systemic venous congestion using the following parameters: Inferior vena cava (IVC) diameter and respiratory collapsibility, Hepatic vein Doppler waveform, Portal vein Doppler pulsatility and Intrarenal venous Doppler pattern.
VExUS score
Change in VExUS score in relation to different PEEP levels in mechanically ventilated patients with ARDS.
Time frame: 3 days
Development of acute kidney injury (AKI)
Development of acute kidney injury (AKI), defined and staged according to the KDIGO criteria: increase in serum creatinine by ≥0.3 mg/dL within 48 hours, or ≥1.5 times baseline within 7 days, or urine output \<0.5 mL/kg/hour for 6 hours.
Time frame: 3 days
Requirement for renal replacement therapy (RRT) during ICU stay.
Requirement for renal replacement therapy (RRT) during ICU stay.
Time frame: 3 days
Length of ICU stay
Length of ICU stay
Time frame: 4 to 7 days
ICU mortality
ICU mortality during ICU Stay
Time frame: 4 to 7 days
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