Effect of Circadian Timing of a Standardized Meal on Postprandial Glucose Response in Healthy Adults

N/ANot Yet RecruitingNCT07545330

King Faisal University32 enrolled

Overview

This randomized crossover study aims to investigate the effect of circadian timing of a standardized meal (morning versus evening consumption) on postprandial glucose response in healthy adults. Postprandial glucose will be assessed using the incremental area under the curve (iAUC) over 120 minutes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Meal Timing Postprandial Glucose Glycemic Response to Feeding in Healthy Participants

Interventions

Standardized Test MealOTHER

The standardized test meal provided 50 g of carbohydrates of weighed portions of white bread and jam, served with 200 mL of water.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adults aged 18 years and older * Able and willing to provide informed consent * Able to comply with study procedures Exclusion Criteria: * Diagnosis of diabetes or any metabolic disorder affecting glucose regulation * Use of any medications * Pregnant or breastfeeding women * Night shift workers or individuals with irregular sleep patterns

Locations (1)

King Faisal University

Al-Ahsa, Eastern Province, Saudi Arabia

Outcomes

Primary Outcomes

Incremental Area Under the Curve (iAUC) for Postprandial Glucose

The primary objective of this study is to investigate the effect of circadian timing of a standardized test meal (morning versus evening consumption) on postprandial glucose response in healthy adults, assessed as the incremental area under the curve (iAUC) for capillary blood glucose over 120 minutes following meal consumption

Time frame: Baseline to 120 minutes after consumption of the standardized test meal

Secondary Outcomes

Peak Postprandial Glucose (Morning vs Evening)

Peak capillary blood glucose concentration measured within 120 minutes after consumption of the standardized test meal, under morning and evening conditions

Time frame: Baseline to 120 minutes after consumption of the standardized test meal

Time to Peak Glucose (Morning vs Evening)

Time required to reach peak capillary blood glucose concentration following meal consumption, under morning and evening conditions.

Time frame: Baseline to 120 minutes after consumption of the standardized test meal

Postprandial Glucose Profile (Morning vs Evening)

Capillary blood glucose concentrations measured at predefined time points following consumption of the standardized test meal, under morning and evening conditions.

Time frame: Baseline, 15, 30, 60, 90, and 120 minutes after consumption of the standardized test meal

Central Contacts

Wafa Alotaibi, PhD

CONTACT

+966500358622 Walotaibi@kfu.edu.sa

Data from ClinicalTrials.gov

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