This prospective observational cohort study aims to evaluate the association between liver fat fraction measured by ultrasound-derived fat fraction (UDFF) and cardiac functional parameters assessed by 2D and 4D HeartAI in adult patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Participants will undergo baseline assessment and repeat evaluations at 6, 12, and 36 months. The study will assess the diagnostic performance of integrated UDFF-HeartAI analysis for detecting subclinical cardiac abnormalities and identify predictors of cardiovascular risk progression and major adverse cardiovascular events in patients with MASLD.
Study Type
OBSERVATIONAL
Enrollment
700
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Incidence of major adverse cardiovascular events (MACE)
Composite of cardiovascular death and non-fatal cardiovascular events, including non-fatal acute myocardial infarction, hospitalization for heart failure, unstable angina, hospitalization for atherosclerotic vascular disease, non-fatal stroke, transient ischemic attack, or lower limb ischemia.
Time frame: Up to 36 months
Subclinical cardiac dysfunction
Defined by abnormalities such as left ventricular ejection fraction \<50% or abnormal left ventricular global longitudinal strain.
Time frame: Baseline, 6 months, 12 months, and 36 months
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