A Proof-of-Concept Study of LAD328 in Adults With Hidradenitis Suppurativa

Inclusion Criteria: * Male or female between 18 and 65 years old inclusive. * A diagnosis of moderate-to-severe HS defined as a total of \>=5 inflammatory lesions (i.e., number of abscesses plus number of inflammatory nodules) at both the Screening and Baseline visits, with a clinical history of HS for at least 6 months. * HS lesions present in at least 2 distinct anatomic areas (e.g., left and right axilla), one of which must be at least Hurley Stage II or Hurley Stage III at both the Screening and Baseline visits. * History of inadequate response, or intolerance or contraindication, to a course of a systemic antibiotics for treatment of HS at the Screening visit. * Agree to regularly use, over-the-counter topical antiseptics on their HS lesions throughout the entirety of the study. * Participants who are woman of child-bearing potential (WOCBP) and male participants must agree to the requirements for the avoidance of pregnancy and exposure of the participant's partner to LAD328 during the trial. Exclusion Criteria: * HS with \>20 draining tunnels either at the Screening or Baseline visits. * Ongoing medical conditions (e.g., inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus and sarcoidosis) requiring systemic immunosuppressive/immunomodulating treatments (e.g., methotrexate, ciclosporin, corticosteroids, cytokine-targeted therapy and JAK inhibitors) during the trial. * Known or suspected hypersensitivity to trial product or any of its excipients. * Hypersensitivity or systemic reaction to a prior biologic (antibody-based) therapy (regardless of indication), that was clinically significant, as per judgment of Investigator. * Prior treatment with LAD328. * Live and attenuated vaccinations 4 weeks prior Pre-treatment or is planning to receive any such vaccine during the trial. * Females who are pregnant or breast-feeding or seeking to become pregnant during the trial.