Bidirectional Cohort Study of a Prognosis Model for Acute-on-chronic Liver Failure

N/AActive Not RecruitingNCT07548190

The Second Affiliated Hospital of Chongqing Medical University2,000 enrolled

Overview

This study constitutes a bidirectional cohort investigation. By collating laboratory parameters and clinical data-including plasma and peripheral blood mononuclear cell (PBMC) analyses-from patients with acute-on-chronic liver failure, it aims to provide a reference framework for predicting prognosis and the occurrence of complications.

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Liver Failure

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: •Clinical diagnosis of Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) Exclusion Criteria: * age \< 18 years * extrahepatic organ failure unrelated to ACLF * active malignancy * co-infection with other hepatitis viruses or human immunodeficiency virus (HIV) * prior liver transplantation * use of immunosuppressants within 6 months before enrollment * unclear history of antiviral therapy

Locations (1)

Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University

Chongqing, China

Outcomes

Primary Outcomes

Primary endpoint was all-cause mortality at days 28, 90, 180, and 360.

Time frame: Days 28, 90, 180, and 360

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.