Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"

Phase 2Not Yet RecruitingNCT07548918

Sohag University30 enrolled

Overview

This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo. It aims to evaluate both clinical and histopathological outcomes in 30 patients with non-segmental stable vitiligo. Vitiligo is a chronic depigmenting disorder caused by melanocyte destruction with significant psychosocial impact. The study also investigates immunohistochemical changes, particularly Wnt/β-catenin signaling expression in lesional skin. The combination therapy is expected to enhance repigmentation by improving melanocyte activation, drug delivery, and angiogenesis

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Vitiligo - Macular Depigmentation

Interventions

Eligibility

Sex: ALLMin age: 16 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with stable non-segmental vitiligo * No new lesions * No enlargement of existing lesions * Patients of both sexes * Age 16 years or older Exclusion Criteria: * Active vitiligo * Pregnant or lactating women * History of keloid formation * Hematological disorders * Coagulopathies * Use of anticoagulant therapy * Use of medications that may prolong bleeding * Previous vitiligo treatment in the last 2 months

Outcomes

Primary Outcomes

Repigmentation in the vitiliginous area after receiving the treatment and increasing the wnt b catenin marker level in the histopathological specimen

Time frame: From enrollment to the end of treatment at 16 weeks for each patient