Comprehensive Oncogenomic Mapping and Exploration in Thoracic and Head & Neck Oncology

Inclusion Criteria: * Ability of participant to understand this study, and participant willingness to sign a written informed consent. NOTE: Remote consenting allowed per IRB policy. * Stated willingness to comply with all study procedures and availability for the duration of the study * Males and/or females age ≥ 18 years * Diagnosis of one of the following: 1. Advanced stage (IIIB to IV) non-small cell lung cancer (all types including mixed histology, without actionable mutations) 2. Extensive-stage small cell lung cancer that are treatment naïve that will receive immunotherapy and chemotherapy 3. Recurrent or metastaƟc squamous cell head and neck cancers, squamous cell, HPV posiƟve or HPV negaƟve, treatment naïve that will start immunotherapy and chemotherapy 4. Malignant pleural mesothelioma that will be treated with immunotherapy and chemotherapy * Eligible to receive chemotherapy (plaƟnum based) with an immune checkpoint inhibitor (single or double agents). * Able to provide consent to obtain a blood sample, prior future genomic research of their samples. * Planning to start therapy in the next 28 days. Exclusion Criteria: * Diagnosed with a psychiatric illness or is in a social situation that would limit compliance with study requirements * Presence of a condition(s) or diagnosis, either physical or psychological, or physical exam finding that precludes participation. * Advanced stage (IIIB to IV) non-small cell lung cancer with actionable mutations * Active viral infection (Hep C or B) requiring anti-viral therapy in the last 28 days. HIV patients on stable on anti-viral therapy able to receive therapy for the cancer are eligible to participate. * Active use of prednisone equivalent to more than 10mg/day * Second malignancy that requires systemic treatment at the time of consent