The goal of this observational study is to evaluate the clinical performance of VeriSee GLC for identifying glaucoma suspects using color fundus images in adult participants. The main questions it aims to answer are: * What are the sensitivity and specificity of VeriSee GLC for detecting glaucoma suspects based on fundus images? * How does the performance of VeriSee GLC compare with the reference standard defined by the majority consensus of three independent evaluators? Researchers will compare the screening results generated by VeriSee GLC with the reference standard to assess its diagnostic performance. This retrospective study will use previously collected fundus images. VeriSee GLC performs automated image analysis to identify glaucomatous signs, including retinal nerve fiber layer (RNFL) defects, vertical cup-to-disc ratio (VCDR) enlargement, and rim-to-disc ratio (RDR) changes. The output is intended to assist healthcare professionals in identifying glaucoma suspects for referral, rather than providing a definitive diagnosis.
Study Type
OBSERVATIONAL
Enrollment
773
National Taiwan University Hospital
Taipei, Taiwan
Sensitivity and Specificity of the VeriSee GLC for Screening Glaucoma Suspects
The primary outcome is the sensitivity and specificity of the VeriSee GLC in identifying glaucoma suspects based on color fundus images, compared against the reference standard defined by the majority consensus of three independent evaluators.
Time frame: 1 Day
Positive Predictive Value (PPV), Negative Predictive Value (NPV), and Accuracy of VeriSee GLC for Screening Glaucoma Suspects
Evaluate the PPV, NPV, and overall accuracy of the VeriSee GLC in identifying glaucoma suspects relative to the reference standard.
Time frame: 1 Day
Accuracy of Detection for 3 Glaucomatous Signs - VCDR and RDR
Assess the accuracy of VeriSee GLC in detecting three glaucomatous signs: * Vertical cup-to-disc ratio (VCDR ≥ 0.7) * Rim-to-disc ratio (RDR ≤ 0.1) * Retinal nerve fiber layer (RNFL) defect
Time frame: 1 Day
Accuracy of Detection for 3 Glaucomatous Signs - RNFL Defect
Assess the accuracy of VeriSee GLC in detecting three glaucomatous signs: * Vertical cup-to-disc ratio (VCDR ≥ 0.7) * Rim-to-disc ratio (RDR ≤ 0.1) * Retinal nerve fiber layer (RNFL) defect
Time frame: 1 Day
Dice Coefficient of Disc and Cup Contours
Dice coefficient measures the similarity between contours generated by VeriSee GLC and evaluator annotations. The Dice coefficient ranges from 0 (no overlap) to 1 (perfect agreement).
Time frame: 1 Day
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