To determine the optimal dosage of Melatonin for preoperative sedation in patients undergoing FESS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
160
comparison between placebo and different melatonin doses(3-5-10 mg)
Aswan university hospitals
Aswān, Egypt
preoperative sedation using ramsay sedation scale
assess of sedation pre-induction of anesthesia and one hour after recovery
Time frame: just before intravenous anesthetic induction and one hour after recovery
perioperative anxiety using The six-item State-Trait Anxiety Inventory (STAI-6) scale
Questionnaire assessment of anxiety
Time frame: Baseline one hour before surgery, just before induction of anaesthesia and one hour after recovery
Measuring heart rate in beat/min
Effect of preoperative different doses of melatonin on heart rate as a part of hemodynamic stability
Time frame: Baseline and perioperative
Measuring blood pressure (systolic, diastolic and mean arterial pressure) in mmHg
Effect of preoperative different doses of melatonin on blood pressure as a part of hemodynamic stability
Time frame: Baseline and perioperative
Measuring oxygen saturation (in percentage) using pulse oximeter
Effect of preoperative different doses of melatonin on oxygen saturation as a part of hemodynamic stability
Time frame: Baseline and perioperative
Postoperative pain assessment using Visual Analogue score of pain
Assessment of the effect of melatonin on postoperative pain management
Time frame: 1,2,4and6 hours postoperative
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