The Impact of Surgical Procedures on Postoperative Outcomes in Cataract Phacoemulsification and Analysis of Related Factors

Zhongshan Ophthalmic Center, Sun Yat-sen University300 enrolled

Overview

The goal of this observational study is to evaluate the location of phacoemulsification tip measured by intraoperative OCT during cataract surgeries and its impact on early postoperative changes of cornea and visual acuity. The main question it aims to answer is: In patients with age-related cataracts undergoing phacoemulsification, does the location (supracapsular, iris-lens diaphragm, or endocapsular) of the phaco tip affect postoperative corneal changes and visual acuity at early postoperative stage? Eyes having phacoemulsification for cataracts will receive intraoperative OCT imaging to evaluate the location of the phaco tip during surgery, and corneal changes and visual acuity will be measured postoperatively.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Age-related Cataract

Interventions

cataract surgeryPROCEDURE

Cataract phacoemulsification combined with intraocular lens implantation

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 50 years and ≤ 90 years * Diagnosis of unilateral/bilateral age-related cataract * Nuclear grade ≥2 in LOCSIII classification * Scheduled for cataract phacoemulsification combined with intraocular lens implantation * Pupil size ≥6mm after dilation * Corneal endothelial cell count ≥1500 cells/mm² Exclusion Criteria: * Diagnosis of severe systemic disease (e.g., severe hypertension or Alzheimer's disease) * History of ocular trauma or surgery * Presence of other ocular diseases (such as glaucoma, diabetic retinopathy, or high myopia) * Other ocular factors that may complicate the surgery (such as small pupil, shallow anterior chamber)

Outcomes

Primary Outcomes

Change in corneal thickness

Corneal thickness measured by corneal endothelial specular microscope

Time frame: postoperative day 1, week 1, and month 1

Secondary Outcomes

Change in corneal endothelial cell density

Measured using corneal endothelial specular microscope

Time frame: 1 day, 1 week, and 1 month postoperatively

Best-corrected visual acuity

Measured using ETDRS visual acuity protocol with ETDRS visual acuity chart by a masked examiner

Time frame: 1 day, 1 week, and 1 month postoperatively

Intraoperative and postoperative complications

Monitored by cataract surgeons using intraoperative OCT and postoperative slit-lamp examination. Complications include Descemet membrane detachment, posterior capsule rupture, incision leakage, and etc.

Time frame: Intraoperative, 1 day, 1 week, and 1 month postoperatively