Background: Borderline personality disorder (BPD) is a frequentand serious psychiatric disorder characterized by a persistent pattern of instability in relationships, affect and self-image. Although long-term follow-up prospective studies have shown high clinical remission rates, they also point out that usually persist social functioning deficits, comorbidity, isolation, chronic affective clinic and life dissatisfaction. Self-compassion training (SCT) could be an effective strategy targeting self-criticism, shame and chronic feelings of worthlessness, as well as increasing resilience. In addition, the administration of intranasal oxytocin has proven useful in regulating social cognition, affiliation behaviors and enhancing empathy, key symptoms in this population. This combined intervention could be particularly appropriate for BPD patients. Objective: The objective of this project is to implement and evaluate the effectiveness of a combined intervention, based on SCT and intranasal oxytocin administration, for the treatment of patients with BPD. Methodology: Controlled and randomized clinical trial. A self-compassion training of 5 weeks duration plus intranasal oxytocin administration versus SCT plus placebo will be compared in a sample of 80 patients with BPD. Clinical and wellness measures will be evalutated as outcomes.
Controlled clinical trial. A self-compassion training of 5 weeks duration plus intranasal oxytocin administration versus SCT plus placebo will be compared in a sample of 80 patients with BPD. Self-criticism, self-compassion, clinical and wellness measures will be evalutated as outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
80
24 UI oxytocin intranasal
24 UI intranasal placebo
SCT consists of a 5 sessions of Self-Compassions meditation training
Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, Spain
RECRUITINGSelf Compassion Scale Short Form (SCS-SF)
Self-Compassion Scale (12 items, minimum 12-maximum 60). Higher scores worse
Time frame: 1 month
Forms of Self-Criticism/Self-Attacking and Self-Reassuring Scale-Short Form (FSCRS-SF)
Self-reported Self-Criticism scale (14 items, minimum 0- maximum 56). Higher scores worse
Time frame: 1 month
Borderline Symptoms List-23 (BSL-23)
Self-reported Borderline Symptoms scale (minimum 0- maximum 92). Higher scores worse
Time frame: 1 week
Satisfaction with life scale (SWLS)
Self-reported satisfaction with life scale (SWLS), well being (5 items, minimum 5 - maximum 25). Higher scores better
Time frame: 1 month
Pemberton Happiness Index (PHI)
Pemberton Happiness Index (minimum 0 - maximum 110). Higher scores better
Time frame: 1 month
OMS WHO-QOL-BREF( WHOQOL-Group, 1998).
Quality of life OMS (26 items, minimum 26 - maximum 130). Higher scores better
Time frame: 2 weeks
Co-IP (JS) JS J Soler
CONTACT
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