IOS Parameters and PAP Titration Pressure in Obstructive Sleep Apnea

N/ANot Yet RecruitingNCT07554430

Mustafa Kemal University92 enrolled

Overview

This prospective observational study aims to investigate whether impulse oscillometry (IOS)-a non-invasive lung function test-can help predict the specific pressure settings needed for positive airway pressure (PAP) therapy in patients with obstructive sleep apnea (OSA). Currently, finding the optimal therapeutic pressure for OSA patients typically requires a titration process during sleep. This study explores if IOS parameters, which measure airway resistance and elasticity through small pressure oscillations during normal breathing, correlate with the final titration pressures (CPAP, EPAP, IPAP, and ΔP) determined by polysomnography. Adult patients diagnosed with moderate-to-severe OSA (Apnea-Hypopnea Index ≥ 15) will undergo standard diagnostic sleep testing followed by IOS testing using the Vyaire Vyntus BodyBox® system. The researchers will evaluate whether these respiratory measurements can accurately predict required airway pressures and if they can help clinicians distinguish between patients who need Continuous Positive Airway Pressure (CPAP) versus Bilevel Positive Airway Pressure (BPAP) therapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obstructive Sleep Apnea (OSA)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults aged 18 to 80 years * Diagnosed with obstructive sleep apnea (OSA) by overnight polysomnography (PSG) * Apnea-hypopnea index (AHI) ≥ 15 * Undergoing positive airway pressure (PAP) titration (CPAP or BPAP) * Able to perform impulse oscillometry (IOS) test * Provided written informed consent Exclusion Criteria: * Central sleep apnea * Neuromuscular disease or restrictive lung disease * Recent upper airway infection (\< 2 weeks) * Incomplete PSG or IOS data * Inability to cooperate with testing procedures

Outcomes

Primary Outcomes

Correlation between baseline impulse oscillometry (IOS) parameters (R5, X5, and Fres) and optimal CPAP pressure.

Evaluating the relationship between specific lung function parameters-specifically total airway resistance (R5), reactance (X5), and resonant frequency (Fres)-measured by a daytime IOS session, and the effective Continuous Positive Airway Pressure (CPAP) determined during the subsequent overnight titration study.

Time frame: From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks)

Secondary Outcomes

Discriminative ability of IOS parameters for CPAP versus BPAP treatment allocation.

Assessing whether baseline impulse oscillometry parameters (R5, X5, Fres, AX) can predict if a patient will require Continuous Positive Airway Pressure (CPAP) or Bilevel Positive Airway Pressure (BPAP) therapy. This will be evaluated using the Area Under the Receiver Operating Characteristic (ROC) Curve.

Time frame: From baseline IOS measurement to completion of the overnight titration study (assessed up to 4 weeks).

Correlation between baseline IOS reactance parameters and bilevel pressure settings (IPAP/EPAP).

Assessing whether baseline impulse oscillometry parameters can predict the specific Inspiratory Positive Airway Pressure (IPAP) and Expiratory Positive Airway Pressure (EPAP) levels required for Bilevel Positive Airway Pressure (BPAP) therapy. This will be evaluated using the correlation coefficient.