the goal of this observation study is to learn about association between intestinal endotoxemia and prediabetes lean patients with the aim of prevention of diabetes in those category of patients
Primary Objective : To determine the correlation between intestinal endotoxemia (measured by serum LBP) and basal beta-cell dysfunction (HOMA-B) in lean prediabetic patients with minimal insulin resistance (HOMA-IR \<1.5). Secondary Objectives: 1. Compare endotoxemia levels (LBP) between lean prediabetic (HOMA-IR \<1.5) and healthy controls. 2. Evaluate LBP's association with fasting glucose and insulin in beta-cell dysfunction phenotype. Hypothesis: In lean prediabetes with beta-cell dysfunction (HOMA-IR \<1.5), serum LBP levels correlate significantly with HOMA-B, indicating endotoxemia-driven beta-cell impairment.
Study Type
OBSERVATIONAL
Enrollment
120
diagnostic tests for prediabetes and intestinal endotoxemia
Sohag University
Sohag, Egypt
correlation between intestinal endotoxemia (measured by serum LBP) and basal beta-cell dysfunction (HOMA-B) in lean prediabetic patients
To determine the correlation between intestinal endotoxemia (measured by serum LBP) and basal beta-cell dysfunction (HOMA-B) in lean prediabetic patients with minimal insulin resistance (HOMA-IR \<1.5).
Time frame: one year
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