The purpose of this study is to understand whether certain brain activity patterns that can appear at the beginning of anesthesia are related to how deep anesthesia remains during the operation. The main question of the study is: Do patients who show a pattern called burst suppression during the start of anesthesia experience deeper anesthesia during surgery? Patients who are scheduled for elective surgery under total intravenous anesthesia (TIVA) may take part in this study. During the operation, brain activity will be monitored using a sensor placed on the forehead (Bispectral Index, BIS monitor), which is already commonly used during anesthesia. Information such as BIS values and the doses of anesthesia medications given during the operation will be recorded. Participation in this study will not change the type of anesthesia or the routine care that patients receive during surgery. The study only involves recording and analyzing information collected during standard anesthesia monitoring.
Study Type
OBSERVATIONAL
Enrollment
200
Amasya University Sabuncuoglu Serefeddin Training and Research Hospital
Amasya, Amasya, Turkey (Türkiye)
Izmir Katip Celebi University Ataturk Training and Research Hospital
Izmir, İzmir, Turkey (Türkiye)
TBIS<40
Total duration during the maintenance phase of anesthesia in which the BIS remains below 40, expressed as a proportion of total surgical time, compared between patients with and without burst suppression during induction
Time frame: During intraoperative period
TBIS40-60
Duration during maintenance anesthesia in which BIS values remain between 40 and 60, expressed as a proportion of total surgical time.
Time frame: During intraoperative period
TBIS>60
Duration during maintenance anesthesia in which BIS remains above 60, expressed as a proportion of total surgical time.
Time frame: During intraoperative period
TLOC
Time to loss of consciousness :Time from induction agent administration to loss of consciousness. Loss of consciousness is defined as the moment when both the eyelash and corneal reflexes are abolished, and the time was recorded in seconds.
Time frame: During induction of anesthesia
BIS-LOC
Bispectral Index (BIS) value at the time of loss of consciousness following induction of anesthesia. Loss of consciousness is defined as the moment when both the eyelash and corneal reflexes are abolished
Time frame: At the exact time of loss of consciousness (LOC)
TROC
Time to return of consciousness:Time from discontinuation of anesthetic agents during the maintenance phase of anesthesia to return of consciousness. Return of consciousness was defined as the moment when the patient regained consciousness, demonstrated by eye opening and/or response to verbal commands, and the time was recorded in seconds
Time frame: During emergence from anesthesia
BIS-ROC
Bispectral Index (BIS) value at the timeof return of consciousness. Return of consciousness was defined as the moment when the patient responded to verbal commands.
Time frame: At the moment of response to verbal commands during emergence from anesthesia
Propofol infusion rate during anesthesia
Propofol administration will be recorded at 1-minute intervals throughout the intraoperative period. Additionally, total drug consumption during the procedure will be obtained from infusion pump records. Values recorded at 1-minute intervals will be used for time-based correlation analyses, while infusion pump data will be used to calculate mean infusion rates. The total amount of propofol administered during the entire surgical procedure will be calculated and expressed as mg/kg/hour.
Time frame: During the intraoperative period
Remifentanil infusion rate during anesthesia
Remifentanil administration will be recorded at 1-minute intervals throughout the intraoperative period. Additionally, total drug consumption during the procedure will be obtained from infusion pump records. Values recorded at 1-minute intervals will be used for time-based correlation analyses, while infusion pump data will be used to calculate mean infusion rates. The total amount of remifentanil administered during the entire surgical procedure will be calculated and expressed as µg/kg/min
Time frame: During the intraoperative period
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