This multicenter, prospective, observational study, based on real-world evidence (RWE), aims to evaluate the efficacy and safety of Platelet-Rich Plasma (PRP) treatment across four types of tendinopathies: patellar, Achilles, epicondylar, and plantar fasciosis. Data collection and analysis will be conducted using the BioSmartData® platform, including hematology analyzers for PRP characterization, clinical variables, treatment protocols, and longitudinal assessment of therapeutic response.
Study Type
OBSERVATIONAL
Enrollment
2,000
A minimal description of the standard PRP preparation and administration protocol will be included to document clinical variability and enable comparative analyses. Across all participating centers, the following variables will be systematically recorded: Type of PRP used (leukocyte-rich vs. leukocyte-poor), with standardized coding Preparation method (single vs. double centrifugation), including specification of the device used Injected volume Anatomical site and administration technique (ultrasound-guided whenever feasible) Number of treatment sessions and interval between sessions
Instituto Médico Arriaza
A Coruña, Spain
RECRUITINGInstituto Cugat
Barcelona, Spain
RECRUITINGReSport Clinic
Barcelona, Spain
RECRUITINGRipoll y dePrado Medical Group
Madrid, Spain
RECRUITINGHospital MIKS
Vitoria-Gasteiz, Spain
RECRUITINGVisual Analog Scale
Time frame: From baseline up to 12 months post-treatment
VISA-P
Change in pain and functional limitation assessed using the Victorian Institute of Sport Assessment-Patella (VISA-P) questionnaire. Scores range from 0 to 100, with higher scores indicating better function and lower pain levels.
Time frame: baseline, 1 month, 3 months, 6 months and 12 months
VISA-A
The VISA-A is an eight item questionnaire measures Achilles tendon pain and function, with scores ranging from 0 to 100 (higher scores indicating better function).
Time frame: baseline, 1 month, 3 months, 6 months and 12 months
Patient Rated Tennis Elbow Evaluation Scale
The Patient-Rated Tennis Elbow Evaluation (PRTEE) is a 15-item self-report questionnaire designed to measure pain and functional disability in patients with lateral epicondylitis (tennis elbow). It includes a 5-item pain subscale and a 10-item function subscale, providing a total score out of 100 to assess, evaluate, and monitor recovery.
Time frame: baseline, 1 month, 3 months, 6 months and 12 months
Foot Function Index
The Foot Function Index (FFI) is a 23-item, self-administered questionnaire designed to measure the impact of foot pathology on function, assessing pain, disability, and activity limitation. It uses a 0-10 Likert scale for items within three subscales, with higher total percentages (0-100%) indicating greater, more severe pain and dysfunction.
Time frame: baseline, 1 month, 3 months, 6 months and 12 months
Predictive factors of response to PRP treatment
Identify clinical patterns predictive of better PRP treatment response using multivariate analysis and artificial intelligence
Time frame: baseline
Adverse events
Assess the incidence of local or systemic adverse events following PRP administration
Time frame: 1 month, 3 months, 6 months, 12 months
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