Telemedicine Self-examination of Speech and Memory for Rapid Detection of Cognitive Impairments Using Machine Learning Methods

N/AEnrolling By InvitationNCT07558785

Faculty Hospital Kralovske Vinohrady500 enrolled

Overview

Early cognitive disorders diagnosis is becoming increasingly important due to population aging. The most common causes include Alzheimer's disease and frontotemporal dementia. These diseases are also manifested by changes in speech. NLP allows us to identify and classify these changes. The project aims to develop a web application for self-assessment and automated detection of cognitive disorders from speech. The application will have a form of a dialogue system using machine learning methods. The novelty of this approach is the possibility of an efficient self-assessment of a wide spectrum of the Czech population from their homes and an automated evaluation of test results. Early detection can be followed by a more detailed diagnosis and adequate treatment.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

500

Conditions

Mild Cognitive Impairment (MCI)Dementia Mild Cognitive Impairment (MCI) Amnestic Frontotemporal Degeneration (FTD)

Interventions

The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)DIAGNOSTIC_TEST

A brief individually administered battery to measure cognitive decline or improvement across five domains in ages 12 to 89 years 11 months.

the Mississippi Aphasia Screening TestDIAGNOSTIC_TEST

he Mississippi Aphasia Screening Test (MAST) was developed as a brief, repeatable screening measure for individuals with severely impaired communication/language skills.

Amnesia Light and Brief Assessment (ALBA)DIAGNOSTIC_TEST

Very brief test used to measure deficits of more cognitive functions (short-term, episodic, semantic amnesia, sensory and motor aphasia, apraxia, psychomotor speed).

The Picture naming and immediate recall test (PICNIR)DIAGNOSTIC_TEST

Very brief test used to measure deficits of more cognitive functions (short-term, episodic, semantic amnesia, sensory and motor aphasia, apraxia, psychomotor speed).

Geriatric Depression Scale (GDS-15)DIAGNOSTIC_TEST

The Geriatric Depression Scale (GDS-15), used to screen for depression in adults aged 55 and older, consists of 15 items that assess mental health based on feelings over the past week.

The Beck Anxiety Inventory (BAI)DIAGNOSTIC_TEST

A formative assessment and rating scale of anxiety.

Digitial Diagnostics of Dementia (DDD)DIAGNOSTIC_TEST

Our experimental screening battery developed for this study.

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria for the group of healthy participants: * age over 45 years * Czech as the native language * must meet the criteria in a questionnaire with questions focused on a history of brain injury or psychiatric history or medication use * must achieve normal scores on questionnaires assessing mood Inclusion Criteria for the group of patients: \- be diagnosed with mild neurocognitive impairment (MCI) or neurocognitive disorder (dementia) according to the international DSM-5 criteria

Locations (3)

Západočeská univerzita v Plzni / Fakulta aplikovaných věd

Pilsen, Czechia

Faculty Hospital Kralovske Vinohrady

Prague, Czechia

Fyzikální ústav AV ČR, v. v. i.

Prague, Czechia

Outcomes

Primary Outcomes

The difference in results between groups of patients with cognitive impairment and healthy individuals in individual parts of our experimental neuropsychological battery Diagnostic Test: Digitial Diagnostics of Dementia (DDD)