Effect of Hyperoxygenated Environment on Maximal Muscle Strength

Assaf-Harofeh Medical Center48 enrolled

Overview

comparing the effect of hyperoxygenated environment on maximal muscle strength in the Mid-thigh Pull Task

All three major energy systems - phosphagen, glycolytic, and oxidative - contribute to any given physical effort. However, it has been widely deemed that the contribution of the oxidative energy system (aerobic) to motor tasks at the very high end of the intensity spectrum, such as maximal muscle strength efforts, is close to negligible. Hyperoxygenated environment includes the inhalation of 100% oxygen at pressures exceeding one atmosphere absolute (ATA) in order to enhance the amount of oxygen dissolved in the body tissues. During hyperbaric chamber treatment, the arterial O2 tension typically exceeds 1500 mmHg, and levels of 200-400 mmHg occur in different body tissues. The isometric mid-thigh pull test (IMTP) is an increasingly popular means to evaluate muscle strength in a multi-joint, large muscle-mass, mostly lower-body motor task. Our study aims to determine whether a high availability of muscle tissue oxygen, by means of hyperbaric oxygenation, can influence the putative small contribution of the oxidative energy system significantly enough to affect peak-force production in a maximal IMTP.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Healthy Lifestyle

Interventions

Hyperbaric Oxygen Therapy - HBOTDEVICE

The HYPEROXYGENATED ENVIRONMENT protocol will include a single exposure to hyperoxic environment. The session will last 60 minutes, of 100% oxygen inhalation by mask at 2 ATA

ShamDEVICE

The Sham protocol will include a single session of breathing 21% oxygen by mask while in the same multi-place chamber. SHAM pressure will go up to 1.2 ATA during the first five minutes of the session (to simulate the pressure sensation in the ears), and then decrease during the next 5 minutes to 1.03 ATA for 55 minutes

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Healthy 2. Ages 18-45 3. Participants are physically active and have a recent resistance-training experience of at least six months, ≥ 3 times a week 4. Participant willing and able to read, understand and sign an informed consent Exclusion Criteria: 1. Inability to attend scheduled clinic visits or comply with the study protocol 2. Active malignancy 3. Active smokers 4. Previous treatment of hyperbaric chamber for any reason prior to study enrollment. 5. Chest pathology incompatible with pressure changes 6. Major orthopedic injury at the past 3 months 7. Inner ear disease 8. Lung pathology 9. Claustrophobia 10. Previous neurologic conditions (e.g., epilepsy, brain tumors or s/p neurosurgery etc.) 11. Comorbidities and medications that rule out the subject

Locations (1)

The Sagol Center for Hyperbaric Medicine and Research Shamir Medical Center

Zrifin, Israel

RECRUITING

Outcomes

Primary Outcomes

Maximal static muscle force production

Participants will perform the isometric mid-thigh pull (IMTP) test using an analog dynamometer that will be purchased for the purpose of the study

Time frame: Baseline evaluation, IMPT test in HBOT chamber, Approximately 4 weeks after the first visit, participants will be exposed to the opposite intervention - HOE or SHAM - and will undergo the same isometric mid-thigh pull (IMTP) test in the chamber.

Central Contacts

Eldad mr Yaakobi

CONTACT

972-8-9779393 yaakobi.eldad@gmail.com

Data from ClinicalTrials.gov

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