Oral Propranolol Versus Fractional Carbon Dioxide CO2 Laser Assisted Delivery of Topical Timolol for Treatment of Infantile Hemangioma

Cairo University30 enrolled

Overview

To assess and compare the efficacy of systemic beta-blocker therapy with the efficacy and safety of fractional carbon dioxide laser-assisted delivery of a topical beta-blocker solution in the treatment of infantile hemangioma.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Infantile Hemangioma (IH)

Interventions

Propranolol 1DRUG

oral propranolol is given daily in a dose of 1 to 2 mgékg daily for 3 months

Fractional CO2 laser with topical timololDEVICE

Weekly sessions were performed followed by application of timolol daily

Eligibility

Sex: ALLMin age: 1 MonthMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: , aged 1 month to 12 years \- presenting with superficial, deep, mixed, or proliferating IH. Exclusion Criteria: * other cutaneous or systemic infections * chronic systemic diseases * known allergy to topical timolol maleate * contraindications to laser or beta-blocker therapy * IH involving mucosal or perimucosal sites * and a history of adverse reactions to laser therapy or keloid tendency.

Locations (1)

Cairo University

Cairo, Egypt

Outcomes

Primary Outcomes

Improvement of global assessment score of infantile hemangioma

Time frame: 3 months

Data from ClinicalTrials.gov

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