Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS. The objective is to analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis and to identify factors associated with this conversion. The study hypothesis is that the presence of internuclear ophthalmoplegia is highly suggestive of multiple sclerosis, particularly when cerebrospinal fluid-specific oligoclonal bands are present.
Study Type
OBSERVATIONAL
Enrollment
200
Les Hôpitaux Universitaires
Strasbourg, France
Analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis.
Proportion of patients with isolated internuclear ophthalmoplegia who converted to multiple sclerosis during follow-up.
Time frame: 1 year
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