A split-side comparative clinical study evaluating the efficacy and safety of injectable platelet-rich fibrin (PRF) versus platelet-rich plasma (PRP), alone or combined with microneedling, in the treatment of striae distensae. Thirty patients received PRF or PRP on one side and combination therapy with microneedling on the contralateral side over five sessions. Outcomes included striae width, length, severity score, and patient satisfaction
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
30
Autologous platelet-rich fibrin prepared via single-spin centrifugation without anticoagulant and injected intradermally
Intradermal injection of platelet-rich plasma
Performed using a dermapen device with 1 mm needle depth, followed by topical application of PRF.
Zagazig University Hospitals
Zagazig, Zagazig--, Egypt
The Imam, Nelva, Alviera score (INA score) (Change in striae severity)
The INA score ranges from 0 to 54, with higher scores indicating greater striae distensae severity, therefore representing a worse outcome. Severity was categorized as mild for scores \<21, moderate for scores 21-40, and severe for scores \>40.
Time frame: baseline to 1 month after last session
Change in striae severity (Imam, Nelva, Alviera score (INA score)
The INA score ranges from 0 to 54, with higher scores indicating greater striae distensae severity, therefore representing a worse outcome. Severity was categorized as mild for scores \<21, moderate for scores 21-40, and severe for scores \>40.
Time frame: 1 month after last session
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Performed using a dermapen device with 1 mm needle depth, followed by topical application of PRP.