The aim of this study is to compare between nebulized dexmedetomidine, ketamine, or midazolam for premedication in children undergoing adenotonsillectomy.
The aim of this study is to compare between nebulized dexmedetomidine, ketamine, or midazolam for premedication in children undergoing adenotonsillectomy. Primary outcome: • A five-point sedation score on arrival in the operating room 30 min after drug administration. Secondary outcomes: * Parental separation anxiety scale. * Medication and mask acceptance scales. * Hemodynamic variables. * Recovery time. * Postoperative face, legs, activity, cry, and consolability (FLACC) scale. * Emergence Agitation scale. * Adverse effects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Patients will receive nebulized ketamine 2 mg kg -1
Patients will receive dexmedetomidine 2 mcg kg -1
Patients will receive midazolam 0.2 mg kg -1
Tanta University
Tanta, Egypt
A five-point sedation score on arrival in the operating room
Sedation level will be assessed at the same time points mentioned above using a five-point sedation scale score as follows: 1= agitated, 2= alert, 3= calm, 4= drowsy, and 5=asleep . A score ≥ 3 will be considered as acceptable sedation.
Time frame: 30 min after drug administration
Parental separation anxiety scale
parental separation will be assessed by a four-point parental separation anxiety scale (PSAS) as follows: 1= easy separation, 2= whimpers, but is easily reassured, not clinging, 3= cries and cannot be easily reassured, but not clinging to parents, and 4= crying and clinging to parents. PSAS scores of 1 and 2 signified acceptable separation whereas scores of 3 and 4 will be classified as difficult separation .
Time frame: 2 hours
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